NAD⁺ and Anti-Aging: What You Need to Know

Aging is inevitable—but how we age can be influenced by science, lifestyle, and the molecules that power our cells. One of the most exciting areas in longevity research centers around NAD⁺ (Nicotinamide Adenine Dinucleotide), a coenzyme present in every cell of the body, and its potential to slow down aging and enhance cellular repair.

As a physician with a focus on health optimization and longevity, I’ve seen firsthand how targeting cellular health can make a significant difference in how patients feel, function, and thrive.

What the Research Says

Several studies have explored NAD⁺ and its precursors—particularly NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside)—for their anti-aging benefits:

• A 2018 study published in Cell Metabolism found that NAD⁺ restoration in aged mice reversed age-related muscle decline and improved mitochondrial function.(Zhang H, et al. Cell Metab. 2016)

• Human studies on NR supplementation have shown increased NAD⁺ levels, improved biomarkers of cardiovascular health, and reduced markers of inflammation.(Martens CR, et al. Nat Commun. 2018)

• A 2020 review in Nature Reviews Molecular Cell Biology emphasized NAD⁺ as a promising therapeutic target for aging and metabolic disease.(Covarrubias AJ, et al.)